common and nonspecific.
## 21. Feeling Cold More Often
Anemia associated with chronic kidney disease can sometimes make people feel unusually cold, even when others are comfortable.
Thyroid problems, low body weight, poor circulation, and other conditions can cause the same symptom.
## 22. High Blood Pressure That Becomes Harder to Control
The relationship between the kidneys and blood pressure works in both directions.
High blood pressure can damage the kidneys, while kidney disease can make blood pressure more difficult to manage.
A noticeable change in previously stable blood pressure may deserve further investigation.
## 23. Chest Pain or Pressure
Chest discomfort can occur in advanced kidney disease, but this is not a symptom to monitor casually.
Chest pain may be caused by serious heart, lung, or circulatory conditions.
Seek urgent medical care if chest pain is:
* sudden
* severe
* worsening
* accompanied by shortness of breath
* associated with fainting or heavy sweating
