500 older adults for 10 years and found that those who regularly used anticholinergics had a 54% increased risk of developing dementia.
Common anticholinergics that have been linked to cognitive decline include meclizine, scopolamine, biperiden, oxybutynin, and diphenhydramine. However, others, such as glycopyrronium and tiotropium, have not been shown to have these effects. Patients and physicians should carefully weigh the risks and benefits of these medications.
Corticosteroids and the Brain
Corticosteroids are used to treat various inflammatory and autoimmune diseases. However, long-term use, especially oral use, can cause serious side effects such as disorientation, anxiety, and depression. A British study found that people who take corticosteroids for a long time had a higher risk of developing dementia.
Glucocorticoids such as prednisone affect brain function by altering levels of the stress hormone cortisol. Even inhaled corticosteroids such as fluticasone can have negative effects if used in high doses or for long
